Gastrointestinal hormones and somatostatin release

Gastrointestinal Hormones: Introduction and Index

Somatostatin, gastrointestinal peptides, and the carcinoid syndrome.

During a control infusion noradrenaline and alcohol each provoked carcinoid flushing in four of five patients and pentagastrin in two of five patients. When tetradecapeptide somatostatin was infused on another day no patient flushed at any time, even when 16 microgram of either noradrenaline or pentagastrin were administered. Carcinoid flushing was not associated with release of gastrin or any ...

Mechanisms regulating somatostatin release and somatostatin-induced acetylcholine release from the myenteric plexus.

The present studies were performed to characterize the molecular form(s) of somatostatin present in the myenteric plexus and to examine some aspects of the regulatory mechanisms underlying somatostatin release and somatostatin-induced release of acetylcholine from this tissue. We observed the following: (1) Somatostatin-like immunoreactivity (SLI) is present in the myenteric plexus of the guine...

Effect of a long-acting octapeptide analogue of somatostatin on growth hormone and pancreatic and gastrointestinal hormones in man.

1. The biochemical specificity and duration of action of a single 5 mg subcutaneous dose of des-AA1,2,4,5,12,13-D-Trp8-somatostatin were evaluated in eight patients with symptomatic pancreatic endocrine tumours. 2. There was a reduction by more than 50% for at least 10 h in plasma concentrations of growth hormone, glucagon, gastrin and motilin and for 4--5 h in plasma insulin, pancreatic polype...

Gut hormones in gastrointestinal disease.

Considerable advances have been made in the understanding of the physiology of gut hormones. Thus, knowledge of the mechanisms of release and of the actions of many of the hormones is rapidly expanding. The known clinical importance of gut hormones is at present confined only to the excess production of gastrin, VIP, and pancreatic glucagon by endocrine tumours. The role of these three and the ...